Edmonton, Alberta – February 23, 2024--Pacylex Pharmaceuticals, a biotechnology company dedicated to developing innovative therapies for cancer and autoimmune diseases, announced that CEO Michael Weickert will attend the upcoming BIO CEO & Investor Conference in NYC and will be meeting with investors regarding the company's Series B funding round. The company's lead candidate, zelenirstat, is a first-in-class, orally bioavailable small molecule myristoylation inhibitor, a new mechanism of action for cancer treatment. Zelenirstat is currently being studied in patients who have failed available treatments (refractory or relapsed; r/r). It is in Phase 2 for patients with r/r B-cell non-Hodgkin lymphoma (NHL) and is about to begin Phase 2a in various r/r solid tumors, especially colorectal cancer, and Phase 1/2 in r/r acute myeloid leukemia (AML). Pacylex recently presented Phase 1 results in gastrointestinal cancers at the ASCO-GI conference in San Francisco in January 2024, including a colorectal patient who had been on therapy for more than 340 days and counting with a reduction in tumor volume and blood cancer marker.
BIO CEO & Investor Conference (BCIC) in New York City, February 26-27, 2024. BCIC is one of the largest investor conferences focused on established and emerging publicly traded and select private biotech companies. The conference brings together institutional investors, industry analysts, and senior biotechnology executives to connect, share insights, and explore promising investment opportunities. Pacylex will be showcasing zelenirstat and seeking partnerships to accelerate the development and commercialization for patients with several different underserved cancers.
Pacylex is a clinical-stage pharmaceutical company headquartered in Edmonton, Alberta, Canada, targeting hematologic and solid cancers with orally bioavailable NMT inhibitors. Zelenirstat is the lead drug in a new class of NMT inhibitors, enabling Pacylex to exploit NMTs as new clinical targets for cancer treatment. Pacylex is conducting a multi-center Phase 1/2a study in Canada in patients with R/R NHL and advanced solid tumors. The IND for a Phase 1 multiple ascending dose study in acute myeloid leukemia (AML) has been cleared and the FDA has granted zelenirstat both Orphan Drug Designation and Fast Track Designation for AML. The US Department of Defense is supporting the initial clinical investigation of zelenirstat in patients with AML. The Cure Cancer Foundation supported initial clinical studies through its World’s Longest Games.
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