Pacylex Pharmaceuticals to Attend 2023 BIO International Convention

Key Takeaways

  • Pacylex CEO Michael Weickert will discuss progress on the PCLX-001 clinical development program, an oral first-in-class NMT inhibitor treatment for patients with hematologic and solid tumor cancers.
  • Pacylex priorities include recruiting a Series B syndicate and identifying regional partners, particularly in Asia.
  • The coming year will provide substantial value drivers as initial results from a Phase 2a study in patients with B-cell Non-Hodgkin Lymphoma become available and a Phase 1/2 study is initiated in patients with Acute Myeloid Leukemia.

Edmonton, Alberta, Canada/May 31, 2023- Pacylex Pharmaceuticals, a clinical-stage company developing PCLX-001, a first-in-class oral investigational small molecule for leukemia, lymphoma, and solid tumor cancers, today announced that it will be attending the Biotechnology Innovation Organization (BIO) International Convention taking place June 5-8, 2023, at the Boston Convention & Exhibition Center, in Boston, Massachusetts, USA. The BIO Convention is the premier life sciences networking conference in the world, bringing together leaders, innovators and investors from the pharmaceutical, biotech and medical device industries.

Pacylex’s Chief Executive Officer, Dr. Michael Weickert, will be attending the conference and participating in the BIO One-on-One Partnering™ system. He will be available to share Pacylex’s recent clinical progress with PCLX-001, including the initiation of a Phase 2a study in patients with B-cell Non-Hodgkin Lymphoma last month, and discuss investment and licensing options. “We are looking forward to discussing our progress on the PCLX-001 clinical development program with potential investors and partners at BIO,” said CEO Michael Weickert. 

Registered attendees can schedule a meeting with Dr. Weickert using the BIO One-on-One Partnering™ system. If there are no compatible time slots available, please contact Dr. Weickert directly to schedule a meeting.


About PCLX-001
PCLX-001 is a first-in-class, oral, small molecule N-myristoyltransferase (NMT) inhibitor being developed to treat patients with leukemia and lymphoma. PCLX-001 selectively kills cancer cells in vitro and has been shown to regress hematologic malignancies and inhibit the growth of lung and breast cancer tumors in animal models. PCLX-001 appears to be particularly effective against Acute Myeloid Leukemia (AML) stem cells in animal disease models. 

The Phase 1/2a study (NCT04836195) is an open-label study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and clinical activity of PCLX-001 in patients with R/R NHL and advanced solid malignancies who have progressed on all available standard therapies. 

About Pacylex Pharmaceuticals
Pacylex is a clinical-stage pharmaceutical company headquartered in Edmonton, Alberta, Canada, targeting hematologic and solid cancers with a first-in-class, oral, once-daily investigational therapeutic, PCLX-001. Pacylex has a US Subsidiary in the San Francisco Bay area. PCLX-001 is the lead drug in a new class of NMT inhibitors, enabling Pacylex to exploit NMTs as new clinical targets for cancer treatment. Pacylex is conducting a multi-center Phase 1 multiple ascending dose study in Canada in patients with R/R NHL and advanced solid tumors, and a Phase 2a dose expansion in patients with R/R NHL.  The US Department of Defense is supporting the initial clinical investigation of PCLX-001 in patients with AML. The FDA has granted PCLX-001 both Orphan Drug Designation and Fast Track Designation for AML. Pacylex received support from an Alberta Innovates AICE grant in 2020, and the research leading to this breakthrough was supported in part by the Alberta Cancer Foundation and the Cure Cancer Foundation. 

 
For additional information, please visit www.pacylex.com.

Contacts:
Pacylex Pharmaceuticals: Michael J. Weickert
CEO, Pacylex Pharmaceuticals, Inc.
P: 650-218-1840
Twitter @Pacylex (https://twitter.com/pacylex
#cancer, #lymphoma, #leukemia, #albertacancer, #Pacylex, #PCLX001, #UAlberta, #MDACC, #BIO2023


Key Takeaways

  • Pacylex CEO Michael Weickert will discuss progress on the PCLX-001 clinical development program, an oral first-in-class NMT inhibitor treatment for patients with hematologic and solid tumor cancers.
  • Pacylex priorities include recruiting a Series B syndicate and identifying regional partners, particularly in Asia.
  • The coming year will provide substantial value drivers as initial results from a Phase 2a study in patients with B-cell Non-Hodgkin Lymphoma become available and a Phase 1/2 study is initiated in patients with Acute Myeloid Leukemia.

Media Gallery

Quotes

We are looking forward to discussing our progress on the PCLX-001 clinical development program with potential investors and partners at BIO.
Michael J. Weickert, PhDCEO

Related Bios

Michael J. Weickert, PhD
CEO
Dr. Weickert has been developing drugs at public and private companies for over 30 years. He has been CEO of Fe Pharmaceuticals, illumiSonics, Sonescence, and SEA Medical Systems, CBO of Strategent Life Sciences, Corium, and Therashock, COO of Greenfire Bio and Ohm Oncology, VP of development at SciDose and Auspex, and Senior Program Executive or Manager at Nektar and Ligand. Michael has driven oncology product development including Phase III/NDA for Targretin for Cutaneous T-cell Lymphoma, and business planning for drug delivery versions of the cancer drugs Leuprolide, Paclitaxel and Irinotecan. He obtained Orphan Drug and Fast Track designations for oncology-related products in the US and EU. Prior to joining the pharmaceutical industry, he was at the National Cancer Institute at NIH. He has a PhD in Genetics from the University of Wisconsin, Madison.
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Luc G. Berthiaume, PhD
Chief Scientific Officer
Luc is a professor of cell biology at University of Alberta with 28 years of experience studying protein fatty acylation. He received his PhD from the Université de Sherbrooke and completed his Post-Doctoral Fellowship at the Memorial Sloan-Kettering Cancer Centre. He has more than 40 publications and 3 patents published or pending. Luc is also the founder and president of Eusera, an antibody manufacturing company in Edmonton, AB, which produces and markets many commercially successful antibodies.
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John Mackey, MD
Chief Medical Officer
John is a medical oncologist and Professor of Oncology, University of Alberta, and Chair of the Alberta Pre-Phase I Cancer Program (www.prephaseone.com). As the former Director of Clinical Trials at the Cross Cancer Institute, and the former Executive Director of Translational Research In Oncology (TRIO), a global clinical trial company with its head office in Edmonton, he has experience with clinical trial operations to expedite the clinical evaluation of Pacylex diagnostics and therapeutics.
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Michele Libonati, MSc
Chief Operating Officer
Michele brings more than 35 years of experience in strategy, preclinical research, clinical development and commercialization of small molecules, large molecules, drug device combinations and gene therapies. Most recently she was SVP of Program Strategy Leadership at Gilead Sciences, where she built a new function of cross-functional leaders accountable for overall program strategy. Prior to Gilead, Michele was CEO of Proneurotech, Inc. (now Nura Bio) a biopharmaceutical start-up focused on discovering and developing neuroprotective drugs. Michele spent 12 years at Genentech/Roche leading neurology, ophthalmology and immunology product strategy and global commercialization. In these roles, she oversaw the successful development and commercialization of a number of innovative flagship products, including OCREVUS®, LUCENTIS® and Rituxan®. Prior to joining Genentech, she held global clinical development leadership positions with Elan Pharmaceuticals, Inc. where she developed TYSABRI® and spent several years working in start-up companies Somatix Therapy Corporation developing gene and cell therapy applications for the treatment of Parkinson’s disease and Alzheimer’s disease, and Transcept Pharmaceuticals, heading the clinical development of Intermezzo®. Michele started the first ten years of her career working in neurology and psychiatric small molecule preclinical research and clinical development at Schering-Plough Research Institute. Michele has a B.A. in Experimental Psychology (now known as Neuroscience) from Rutgers University and M.S. in Pharmacology from New York Medical College.
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Contacts

Michael Weickert Ph.D
michael.weickert@pacylex.com
650-218-1840
Chief Executive Officer