Pacylex Pharmaceuticals Selected as One of Sixteen Canadian Startup Companies to Present at Sweet Biopharma Day 2023

Pacylex Will Also Present at Creative Destruction Labs (CDL) Alumni Showcase.

Key Takeaways

  • Pacylex was selected by a panel of pharmaceutical industry professionals to be one of 16 Canadian companies to present at the 3rd annual Sweet Biopharma Day, an invitation-only event, on April 12, 2023.
  • Pacylex will also present at the invitation-only CDL-Vancouver's Alumni Showcase on April 19, 2023.
  • In between these events, Pacylex will present exciting new scientific results at the AACR Annual meeting in Orlando, Florida.

Edmonton, Alberta, Canada/April 10, 2023- Pacylex Pharmaceuticals today announced it will be presenting at two exclusive life science startup events in Canada in April, spotlighting its emergence as one of the premier Canadian biotech startup companies. Pacylex is focused on innovative research and development and is a leader in the maturing Canadian biotech ecosystem.

A panel of pharmaceutical industry professionals selected Pacylex as one of only 16 Canadian startup companies to highlight at the annual Sweet Biopharma Day on April 12 in Mirabel, Québec. The following week, Pacylex will present at another invitation-only event, the Creative Destruction Labs (CDL)-Vancouver's Alumni Showcase on April 19.  Pacylex was part of the CDL’s Health cohort in 2020 that was cut short by the COVID-19 pandemic.

At these events, CEO Michael Weickert will present the company’s progress and plans, highlighting clinical results and the potential of PCLX-001, a first-in-class, oral NMT inhibitor being developed by the company. The company’s Founder and CSO, Luc Berthiaume, will also attend the Sweet Biopharma Day. In between these events, advances in discovery research regarding NMT inhibition will be presented at the American Association for Cancer Research (AACR) Annual Meeting from April 14-19, 2023.

Participants at the Sweet Biopharma Day and CDL Alumni events include stakeholders from key global pharma and biopharma companies, support organizations, venture capitalists, and representatives from governments and associations. “We are honored to be offered the opportunity to participate at these events featuring the best of the emerging biotech companies in Canada,” said Michael Weickert, CEO of Pacylex. “As a member of BIOTECanada, we believe the Canadian biotech ecosystem is an economic strength that positions Canada well to successfully deliver innovation to a world looking for solutions, and we want to showcase how science at Pacylex is being translated into first-in-class products with the potential to dramatically impact patient care.”


About PCLX-001
PCLX-001 is a first-in-class, oral, small molecule N-myristoyltransferase (NMT) inhibitor being developed to treat patients with leukemia and lymphoma. PCLX-001 selectively kills cancer cells in vitro and has been shown to regress hematologic malignancies and inhibit the growth of lung and breast cancer tumors in animal models. PCLX-001 appears to be particularly effective against AML stem cells in animal disease models. PCLX-001 is currently being studied in patients with Non-Hodgkin’s Lymphoma (NHL) and solid tumor malignancies. More than 20 patients with cancer have received PCLX-001 with no dose limiting toxicities. 

About Pacylex Pharmaceuticals
Pacylex is a clinical-stage pharmaceutical company headquartered in Edmonton, Alberta, Canada, targeting hematologic and solid cancers with a first-in-class, oral, once daily therapeutic, PCLX-001. Pacylex has a US Subsidiary in the San Francisco Bay area. PCLX-001 is the lead drug in a new class of N-myristoyltransferase (NMT) inhibitors, enabling Pacylex to exploit NMTs as new clinical targets for cancer treatment. Pacylex is conducting a multi-center Phase 1 multiple ascending dose study in Canada in patients with Diffuse Large B Cell Lymphoma (DLBCL) and solid tumors, and a Phase 2a dose expansion in patients with Non Hodgkin Lymphoma (NHL) is planned to start in Q2 2023 (ClinicalTrials.gov Identifier: NCT04836195). A Phase 1/2a clinical study in patients with Acute Myeloid Leukemia (AML) is also planned to start in Q2 2023. The US Department of Defense is supporting the initial clinical investigation of PCLX-001 in patients with AML. The FDA has granted PCLX-001 both Orphan Drug Designation and Fast Track Designation for AML. Pacylex received support from an Alberta Innovates AICE grant in 2020, and the research leading to this breakthrough was supported in part by the Alberta Cancer Foundation and the Cure Cancer Foundation. For additional information, please visit www.pacylex.com.


For more information:
Pacylex Pharmaceuticals Contact: Michael J. Weickert
CEO, Pacylex Pharmaceuticals, Inc.
P: 650-218-1840
Twitter @Pacylex (https://twitter.com/pacylex
#cancer, #lymphoma, #leukemia, #albertacancer, #Pacylex, #PCLX001, #UAlberta; #UAlberta_FoMD; #Worldslongestgame, #AACR23, #MDACC, #NHL

Key Takeaways

  • Pacylex was selected by a panel of pharmaceutical industry professionals to be one of 16 Canadian companies to present at the 3rd annual Sweet Biopharma Day, an invitation-only event, on April 12, 2023.
  • Pacylex will also present at the invitation-only CDL-Vancouver's Alumni Showcase on April 19, 2023.
  • In between these events, Pacylex will present exciting new scientific results at the AACR Annual meeting in Orlando, Florida.

Media Gallery

Quotes

As a member of BIOTECanada, we believe the Canadian biotech ecosystem is an economic strength that positions Canada well to successfully deliver in...
Michael J. Weickert, PhDCEO

Related Bios

Michael J. Weickert, PhD
CEO
Dr. Weickert has been developing drugs at public and private companies for over 30 years. He has been CEO of Fe Pharmaceuticals, illumiSonics, Sonescence, and SEA Medical Systems, CBO of Strategent Life Sciences, Corium, and Therashock, COO of Greenfire Bio and Ohm Oncology, VP of development at SciDose and Auspex, and Senior Program Executive or Manager at Nektar and Ligand. Michael has driven oncology product development including Phase III/NDA for Targretin for Cutaneous T-cell Lymphoma, and business planning for drug delivery versions of the cancer drugs Leuprolide, Paclitaxel and Irinotecan. He obtained Orphan Drug and Fast Track designations for oncology-related products in the US and EU. Prior to joining the pharmaceutical industry, he was at the National Cancer Institute at NIH. He has a PhD in Genetics from the University of Wisconsin, Madison.
View Full Bio>>
Luc G. Berthiaume, PhD
Chief Scientific Officer
Luc is a professor of cell biology at University of Alberta with 28 years of experience studying protein fatty acylation. He received his PhD from the Université de Sherbrooke and completed his Post-Doctoral Fellowship at the Memorial Sloan-Kettering Cancer Centre. He has more than 40 publications and 3 patents published or pending. Luc is also the founder and president of Eusera, an antibody manufacturing company in Edmonton, AB, which produces and markets many commercially successful antibodies.
View Full Bio>>
Michele Libonati, MSc
Chief Operating Officer
Michele brings more than 35 years of experience in strategy, preclinical research, clinical development and commercialization of small molecules, large molecules, drug device combinations and gene therapies. Most recently she was SVP of Program Strategy Leadership at Gilead Sciences, where she built a new function of cross-functional leaders accountable for overall program strategy. Prior to Gilead, Michele was CEO of Proneurotech, Inc. (now Nura Bio) a biopharmaceutical start-up focused on discovering and developing neuroprotective drugs. Michele spent 12 years at Genentech/Roche leading neurology, ophthalmology and immunology product strategy and global commercialization. In these roles, she oversaw the successful development and commercialization of a number of innovative flagship products, including OCREVUS®, LUCENTIS® and Rituxan®. Prior to joining Genentech, she held global clinical development leadership positions with Elan Pharmaceuticals, Inc. where she developed TYSABRI® and spent several years working in start-up companies Somatix Therapy Corporation developing gene and cell therapy applications for the treatment of Parkinson’s disease and Alzheimer’s disease, and Transcept Pharmaceuticals, heading the clinical development of Intermezzo®. Michele started the first ten years of her career working in neurology and psychiatric small molecule preclinical research and clinical development at Schering-Plough Research Institute. Michele has a B.A. in Experimental Psychology (now known as Neuroscience) from Rutgers University and M.S. in Pharmacology from New York Medical College.
View Full Bio>>
John Mackey, MD
Chief Medical Officer
John is a medical oncologist and Professor of Oncology, University of Alberta, and Chair of the Alberta Pre-Phase I Cancer Program (www.prephaseone.com). As the former Director of Clinical Trials at the Cross Cancer Institute, and the former Executive Director of Translational Research In Oncology (TRIO), a global clinical trial company with its head office in Edmonton, he has experience with clinical trial operations to expedite the clinical evaluation of Pacylex diagnostics and therapeutics.
View Full Bio>>
Annette Marcantonio
VP Clinical Operations
Annette joined Pacylex as Vice President, Clinical Operations after more than 30 years in senior clinical operations and development roles, leading large-scale clinical programs in complicated and novel therapeutic areas. Prior to Pacylex, she served as Vice-President of Clinical Affairs at Neurogastrx, where she successfully progressed the NG101 program in Gastroparesis. Prior to Neurogastrx, she served as Vice-President of Clinical Operations at Aimmune, where she was a key figure in designing the clinical development program and implemented and managed the studies leading to the approval of the first-in-class peanut allergy treatment Palforzia™. At prior companies, she has been a key participant in the filings of several US and EU marketing applications and has held key leadership positions in programs that have directly contributed to successful product approvals and label expansions for multiple drugs and biologics. Over the past two decades, Annette has also provided consulting support to numerous bio-pharmaceutical companies to support their development programs, and in one case served as a client's regulatory representative to the FDA. Annette received her Bachelor's degree from Loyola-Marymount University.
View Full Bio>>
Ryan Heit, MSc, MBA
VP Operations
Ryan has a background in research, technology commercialization, business development, and financing early stage companies. Ryan has provided business planning and company development for many early-stage, technology-based ventures in health-related fields in his previous positions as the Director of the Merck Invention Accelerator, with the University of Alberta, TEC Edmonton, and as an independent consultant. He also has nearly a decade of experience in the angel investing space as a Co-Founder and investor in Valhalla Private Capital. He holds a Masters in Experimental Oncology and an MBA from the University of Alberta.
View Full Bio>>

Contacts

Michael Weickert Ph.D
michael.weickert@pacylex.com
650-218-1840
Chief Executive Officer